On-Demand Webinar

One peptide, three orthogonal routes: Notes from a Semaglutide synthesis program.

View this on-demand webinar to learn from Lucrezia Sforzi (PhD candidate, PeptLab, University of Florence / PECS Lab) and Dr. Manoj Kumar Muthyala (Gyros Protein Technologies / PECS Lab) as they share insights from a Semaglutide synthesis program comparing three orthogonal strategies for lipid side-chain introduction. Discover how each approach impacts purity, yield, process complexity, and scalability — from early-stage research through pilot-scale peptide production.

This webinar presents a direct comparison of three strategies for introducing the lipid side chain at Lys26 during Semaglutide synthesis. Lucrezia Sforzi will share experimental results generated on the PurePep® Chorus, covering the impact of each approach on purity, recovery, and overall process performance.

Building on these findings, Dr. Manoj Kumar Muthyala will discuss key considerations for scaling peptide synthesis from R&D to pilot production on the PurePep® Sonata®+. The session will include case studies featuring GLP-1 receptor agonists and MRI imaging agents, highlighting practical lessons for route selection, process optimization, and successful scale-up.

YOU WILL LEARN:

• How three orthogonal routes to one modified peptide compare on purity, recovery, and operational complexity
• What changes (and what doesn't) when a chosen route moves from PurePep Chorus to pilot-scale PurePep Sonata+
• PurePep Sonata+ scale-up across modalities: GLP-1 receptor agonists and a multi-gram MRI agent for in vivo studies

Speakers:

Lucrezia Sforzi

PhD candidate, PeptLab, University of Florence / Visiting Researcher, PECS Lab (Berlin)

Dr. Manoj Kumar Muthyala

Gyros Protein Technologies / R&D Scientist, PECS Lab (Berlin)